PANRE practice questions, PANRE practice exams and a PANRE practice test for recertification
Recertifying is a different problem from certifying. You have been practicing in one specialty for a decade, the PANRE blueprint is deliberately broad core medicine, and the areas you have not touched since rotations are exactly where it will find you. The fix is not rereading a textbook. It is working core medical questions across the whole blueprint until your weak areas stop being weak.
- Unlimited PANRE-style questions on the NCCPA core medical blueprint
- Every answer choice explained, so you rebuild reasoning and not just recall
- Useful whether you sit the test-center PANRE or work through PANRE-LA quarters
Questions are generated on each exam's current published format, verified July 2026. Plans from $9/mo, cancel anytime.
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The short answer
The PANRE (Physician Assistant National Recertifying Examination) is 240 multiple-choice questions in four blocks of 60, with 60 minutes per block, so it is 4 hours of testing in a 5-hour appointment at a Pearson VUE center. It is scored 200 to 800 and you need 379 to pass, a higher cut score than the PANCE. You are eligible in year 9 or 10 of your 10-year certification maintenance cycle, the fee is $350, and you get a maximum of four attempts. The alternative is PANRE-LA, a take-at-home longitudinal assessment of 25 questions per quarter across years 7 to 9, scored 1000 to 1500 with a passing score of 1150. Both cost $350 and both are built on the same core medical blueprint.
Last updated July 2026
Work the questions
PANRE sample questions with answers and explanations
Six recertification-level questions on core medical content, the kind of primary care reasoning the PANRE and PANRE-LA blueprint targets. Read every rationale, including why the wrong answers are wrong.
Question 1 · Cardiovascular
A 74-year-old woman is found to have newly diagnosed nonvalvular atrial fibrillation on a routine ECG. Her history includes hypertension, type 2 diabetes and a transient ischemic attack 3 years ago. Which of the following is the most appropriate long-term therapy to reduce her stroke risk?
- A. Aspirin 81 mg daily
- B. A direct oral anticoagulant such as apixaban
- C. Clopidogrel 75 mg daily
- D. No antithrombotic therapy
Show the answer and explanation Answer
B. A direct oral anticoagulant such as apixaban
Her CHA2DS2-VASc score is 6: hypertension 1, diabetes 1, prior TIA 2, age 65 to 74 gives 1, and female sex 1. Anticoagulation is recommended at a score of 2 or more in women, and direct oral anticoagulants are preferred over warfarin in nonvalvular atrial fibrillation because they achieve comparable or better stroke prevention with less intracranial bleeding and no INR monitoring. Antiplatelet therapy (A and C) is inadequate for cardioembolic stroke prevention in atrial fibrillation, a point older guidance got wrong and current guidance is explicit about. Doing nothing (D) leaves a high annual stroke risk untreated.
Question 2 · Preventive medicine
A healthy 45-year-old man with no family history of colorectal cancer and no gastrointestinal symptoms asks when he should begin colorectal cancer screening. Which of the following is the most appropriate recommendation?
- A. Begin screening now
- B. Begin at age 50
- C. Begin at age 40 only if symptoms develop
- D. Screening is not indicated without a family history
Show the answer and explanation Answer
A. Begin screening now
The US Preventive Services Task Force lowered the starting age for average-risk colorectal cancer screening from 50 to 45 in 2021, aligning with the American Cancer Society and responding to rising incidence in younger adults. Acceptable strategies include colonoscopy every 10 years, annual fecal immunochemical testing, stool DNA testing every 1 to 3 years, or CT colonography every 5 years, and the best test is largely the one the patient will actually complete. Screening continues through age 75, with individualized decisions from 76 to 85. Answer (B) reflects the superseded recommendation, and a family history (D) changes when and how often you screen, not whether.
Question 3 · Endocrinology
A 58-year-old man with type 2 diabetes has an A1c of 8.4 percent on maximally tolerated metformin. He also has heart failure with reduced ejection fraction and an eGFR of 48 mL/min/1.73 m2. Which of the following is the most appropriate agent to add?
- A. Glipizide
- B. An SGLT2 inhibitor such as empagliflozin
- C. Pioglitazone
- D. Basal insulin
Show the answer and explanation Answer
B. An SGLT2 inhibitor such as empagliflozin
SGLT2 inhibitors reduce heart failure hospitalization and slow chronic kidney disease progression independent of their glucose-lowering effect, which is why guidelines make them the preferred add-on once heart failure or CKD is present, rather than choosing purely on A1c. Pioglitazone (C) causes fluid retention and is contraindicated in symptomatic heart failure. Sulfonylureas (A) bring hypoglycemia and weight gain with no cardiorenal benefit. Basal insulin (D) would lower the A1c but does nothing about the comorbidities that will actually determine this patient outcome.
Question 4 · Pulmonary and infectious disease
A previously healthy 38-year-old woman with no antibiotic use in the past 3 months presents with 4 days of fever, productive cough and pleuritic chest pain. She is hemodynamically stable with an oxygen saturation of 96 percent, and chest radiograph shows a right lower lobe infiltrate. Her CURB-65 score is 0. Which of the following is the most appropriate outpatient treatment?
- A. High-dose amoxicillin
- B. Levofloxacin
- C. Intravenous ceftriaxone and azithromycin
- D. Oseltamivir
Show the answer and explanation Answer
A. High-dose amoxicillin
For an otherwise healthy adult with no comorbidities and no recent antibiotic exposure, community-acquired pneumonia guidance recommends amoxicillin, doxycycline, or a macrolide where local pneumococcal macrolide resistance is below 25 percent. Respiratory fluoroquinolones (B) are held back for patients with comorbidities or recent antibiotics, given tendon rupture, CNS effects and aortic aneurysm risk. Intravenous therapy (C) is for admitted patients, and a CURB-65 of 0 supports outpatient management. Oseltamivir (D) treats influenza and would not address a bacterial lobar pneumonia.
Question 5 · Nephrology and hypertension
A 55-year-old man with type 2 diabetes has a blood pressure of 148/92 mm Hg confirmed on repeat measurement and a urine albumin-to-creatinine ratio of 320 mg/g. Which of the following is the most appropriate initial antihypertensive?
- A. Hydrochlorothiazide
- B. Lisinopril
- C. Amlodipine
- D. Metoprolol
Show the answer and explanation Answer
B. Lisinopril
With diabetes and albuminuria, an ACE inhibitor or an ARB is first-line because it lowers intraglomerular pressure and slows diabetic kidney disease progression beyond what blood pressure reduction alone achieves. Check a basic metabolic panel 2 to 4 weeks after starting: a creatinine rise of up to roughly 30 percent is expected and is not a reason to stop, while a larger jump raises the question of bilateral renal artery stenosis. Thiazides (A) and dihydropyridine calcium channel blockers (C) are perfectly reasonable first-line choices in the absence of albuminuria, and beta blockers (D) are not first-line for uncomplicated hypertension.
Question 6 · Musculoskeletal
A 52-year-old man has had a third episode of acute gout in 14 months. Between attacks his serum urate is 9.2 mg/dL and he has a visible tophus on the right olecranon. Which of the following is the most appropriate long-term management?
- A. Colchicine only during acute attacks
- B. Start allopurinol and titrate to a serum urate below 6 mg/dL
- C. Advise a low-purine diet alone
- D. Begin allopurinol during the next acute attack only
Show the answer and explanation Answer
B. Start allopurinol and titrate to a serum urate below 6 mg/dL
Urate-lowering therapy is indicated when a patient has two or more flares per year, any tophus, or radiographic joint damage, and this patient meets two of those criteria. Allopurinol is first-line, started low at around 100 mg daily and lower in chronic kidney disease, then titrated to a serum urate target below 6 mg/dL. Cover the first 3 to 6 months with low-dose colchicine or an NSAID, because shifting urate levels can trigger flares and that is the usual reason patients abandon therapy. Dietary change alone (C) rarely lowers serum urate by more than about 1 mg/dL. Treating flares only (A) leaves the tophus and ongoing joint destruction untouched.
These six are a sample. Inside Aspirants.ai you can generate unlimited PANRE-style questions on any core medical area, with the same depth of explanation on every answer choice.
Generate more questions freeWhat the PANRE looks like
The PANRE is 240 multiple-choice questions delivered in four blocks of 60, with 60 minutes for each block. That is 4 hours of testing time, and with the 15-minute tutorial and 45 minutes of total break time you can split between blocks, NCCPA schedules a 5-hour appointment. It is given at more than 200 Pearson VUE test centers in the United States plus select international centers, throughout the year except for the last few weeks of the calendar year. Once you submit a block you cannot return to it, so pace at roughly a minute per question and flag anything you want to revisit before the block closes.
- 240 questions, four blocks of 60, 60 minutes per block
- 4 hours of testing inside a 5-hour scheduled appointment
- 45 minutes of total break time plus a 15-minute tutorial
- Over 200 US Pearson VUE centers, year-round with a year-end pause
What is a passing score on the PANRE?
The PANRE is reported on a scale from 200 to 800 and the passing score is 379. That is worth pausing on, because the PANCE uses the same 200 to 800 scale with a passing score of 350. The two numbers are set by separate standard-setting panels against different blueprints, so a 379 on the PANRE is not simply "29 points harder" than a PANCE pass. What it does tell you is that clearing recertification is not a formality, and that scores from the two exams cannot be compared directly. PANRE-LA is reported on a completely different scale, 1000 to 1500, with a passing score of 1150. Both are pass or fail once the decision is made.
- PANRE: scale 200 to 800, passing score 379
- PANRE-LA: scale 1000 to 1500, passing score 1150
- The PANCE passing score is 350 on the same 200 to 800 scale
- Scores from PANRE and PANRE-LA are not comparable to each other
PANRE vs PANRE-LA: how the two options actually differ
Since 2023 every board certified PA has had two ways to meet the recertification exam requirement, and the fee is $350 either way. PANRE is one proctored sitting at a test center in year 9 or 10 of your cycle. PANRE-LA is a longitudinal assessment: you apply in year 6, questions begin in January of year 7, and you answer 25 questions per quarter across years 7, 8 and 9. Each PANRE-LA question carries a 5-minute limit, you may use online or printed references, you can take it on any compatible device, and you get immediate feedback with a rationale and references after every question. You also earn Category 1 CME for each quarter you complete. Twelve quarters are available, you must complete at least eight, you may skip up to four, and you must take at least one quarter in each of years 7, 8 and 9.
- Same $350 fee and the same core medical blueprint either way
- PANRE: one proctored sitting, year 9 or 10, closed book
- PANRE-LA: 25 questions a quarter, 5 minutes each, open reference, any device
- PANRE-LA earns Category 1 CME for every quarter completed
How PANRE-LA scoring works, and the part most PAs miss
Your PANRE-LA score is built from your best eight quarters, not your first eight and not all twelve. Scoring for a pass or fail decision starts once you have completed eight quarters, and if you have reached 1150 at that point you are done and exit the program early, potentially finishing in two years rather than three. If you have not reached the standard, you stay in and your score is recalculated after each additional quarter, always using the highest-scoring eight. That design is forgiving in a way a single sitting is not: a bad quarter early on can be dropped entirely. And if you finish all twelve quarters without passing, you have not lost recertification, because you still get up to three PANRE attempts in year 10.
- Only your best 8 of 12 quarters count toward the final score
- Reach 1150 after eight quarters and you exit early
- Scores recalculate after every additional quarter you take
- Failing PANRE-LA still leaves up to three PANRE attempts in year 10
What is on the PANRE: the core medical blueprint
The recertification exams do not use the PANCE blueprint. In 2019 NCCPA adopted a separate content blueprint for PANRE and PANRE-LA that focuses on core medical knowledge, meaning the content considered essential for every clinically practicing PA regardless of specialty, rather than the broader general blueprint the PANCE uses. It was refreshed after the 2021 practice analysis and the current version went live in 2023. Practically, this is good news for a PA who has spent ten years in orthopedics or dermatology: the exam is not trying to test you on the deepest corners of every specialty. It is testing whether you have kept the core. The trap is assuming "core" means "easy," and skipping the systems you genuinely have not seen since school.
- A separate core medical blueprint, not the PANCE general blueprint
- Adopted 2019, updated from the 2021 practice analysis, live since 2023
- The same blueprint underpins both PANRE and PANRE-LA
- Breadth across core medicine matters more than specialty depth
How many times can you take the PANRE?
You are eligible to sit the PANRE in the ninth or tenth year of your certification maintenance cycle, with a maximum of four attempts overall: up to two in year 9 and up to three in year 10. After your application is complete you get a 180-day window to schedule and test. The practical advice is to use year 9 rather than saving it all for year 10, because an early attempt leaves you room to recover, and a first attempt in year 10 leaves very little. Remember the exam is only half of it: you also have to earn and log 100 CME credits in each two-year cycle and pay the certification maintenance fee by December 31 of your expiration year.
- Eligible in year 9 or year 10 of the 10-year cycle
- Up to two attempts in year 9, up to three in year 10, four maximum
- A 180-day scheduling window once your application is complete
- 100 CME credits per two-year cycle run alongside the exam requirement
Compare the options
PANRE vs PANRE-LA compared
Both options cost $350, both use the same core medical blueprint, and both satisfy the recertification exam requirement. Everything else is different. Specifications verified against NCCPA.
| PANRE | PANRE-LA | |
|---|---|---|
| Format | One proctored sitting at a Pearson VUE center | 25 questions per quarter, taken at home on any device |
| Length | 240 questions, four blocks of 60 | 25 questions a quarter, up to 12 quarters |
| Timing | 60 minutes per block, 4 hours of testing | 5 minutes per question |
| References allowed | No, closed book | Yes, online or printed references permitted |
| When | Year 9 or 10 of your cycle | Apply in year 6, questions across years 7 to 9 |
| Score scale | 200 to 800, passing score 379 | 1000 to 1500, passing score 1150 |
| Scoring rule | One sitting, one result | Best 8 of 12 quarters count |
| Attempts | Up to 4 total: two in year 9, three in year 10 | Fail and you still get up to 3 PANRE attempts in year 10 |
| Feedback | Score report after the exam | Immediate rationale and references after each question |
| CME | None for the exam itself | Category 1 CME for every quarter completed |
| Fee | $350 | $350 |
Specifications from NCCPA. The 2019 to 2020 Pilot Alternative to PANRE, the forerunner of PANRE-LA, enrolled more than 18,000 PAs, of whom over 98 percent continued for the full two years and 97.5 percent passed, per NCCPA. That is pilot data on a voluntary group, not a published PANRE-LA pass rate. Verify current fees and dates with NCCPA before you apply.
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The PANRE has 240 multiple-choice questions delivered in four blocks of 60, with 60 minutes to complete each block. That is 4 hours of testing time. Adding the 15-minute tutorial and 45 minutes of total break time you can distribute between blocks, NCCPA schedules a 5-hour appointment at the Pearson VUE test center.
You need a scaled score of 379 to pass the PANRE, on a scale running from 200 to 800. PANRE-LA uses a separate scale from 1000 to 1500 with a passing score of 1150. Both are ultimately pass or fail. Note that the PANCE passing score is 350 on the same 200 to 800 scale, but the two cut scores come from different standard-setting panels and different blueprints, so they are not directly comparable.
PANRE-LA suits most practicing PAs better: it spreads 25 questions per quarter across three years, allows references, gives immediate rationales, earns Category 1 CME, and counts only your best 8 of 12 quarters. The traditional PANRE suits you if you would rather finish in one sitting, you missed the year 6 application window, or you prefer a defined end date over a three-year commitment. The fee is $350 either way.
You get a maximum of four PANRE attempts: up to two in year 9 of your certification maintenance cycle and up to three in year 10. Once your application is complete you have a 180-day window to schedule and sit the exam. If you go the PANRE-LA route and do not reach the passing standard after 12 quarters, you still have up to three PANRE attempts in year 10.
The NCCPA fee is $350, and it is the same whether you choose the traditional PANRE or PANRE-LA. That is separate from the certification maintenance fee and from any prep you buy. You also have to earn and log 100 CME credits in each two-year cycle across the 10-year certification maintenance period.
They are different exams rather than harder or easier versions of the same one. The PANRE is shorter at 240 questions versus 300, and it uses a core medical blueprint focused on knowledge essential to every practicing PA rather than the broader general blueprint of the PANCE. The higher cut score, 379 against the PANCE 350, reflects separate standard-setting panels, not a directly harder test. In practice PAs find the challenge is breadth outside their specialty after a decade of focused practice.
PANRE and PANRE-LA share a content blueprint that NCCPA adopted in 2019 and refreshed following its 2021 practice analysis, with the current version live since 2023. It deliberately targets core medical knowledge relevant to every clinically practicing PA regardless of specialty, rather than the broader general blueprint used for the PANCE. The blueprint spells out the diseases, disorders and knowledge levels covered.
Yes. PANRE-LA permits online or printed references while you answer, and each question carries a 5-minute limit. That is one of the biggest practical differences from the traditional PANRE, which is closed book at a proctored test center. Before you open each PANRE-LA question you are told which content category it covers, so you can defer it until later in the quarter if you want to review first.
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